Narcolepsy with Cataplexy: Diagnosis and Sodium Oxybate Treatment
11 Feb 2026Narcolepsy with cataplexy is a rare neurological disorder causing sudden sleep attacks and muscle weakness triggered by emotion. Diagnosis requires specialized testing like MSLT and CSF hypocretin measurement. Sodium oxybate (Xyrem/Xywav) is the only FDA-approved treatment that effectively reduces both excessive sleepiness and cataplexy, though access remains limited by cost and complexity.