If you’ve heard the term “aromatase inhibitor” and wonder what it means, you’re in the right place. Aromatase inhibitors (AIs) are drugs that lower estrogen levels in the body by blocking the enzyme aromatase. That enzyme turns testosterone into estrogen, so when it’s blocked, estrogen drops.
Doctors mostly use AIs to treat hormone‑positive breast cancer in post‑menopausal women. Lower estrogen means slower tumor growth. They’re also sometimes used in fertility clinics to boost testosterone in men or to help women with certain hormonal issues.
The three most prescribed AIs are anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin). All three lower estrogen, but they have slight differences:
Each drug has its own dosing guide, so follow your doctor’s prescription exactly.
Because estrogen does more than just affect breast tissue, cutting it down can cause side effects. Common issues include joint pain, hot flashes, fatigue, and occasional bone loss. Your doctor may order a bone density scan if you stay on an AI for a long time.
If you notice severe joint pain, sudden mood changes, or unexplained bruising, call your doctor. Some people add calcium and vitamin D supplements to protect bone health, but only do that after checking with a healthcare professional.
Most side effects are manageable, and many patients feel better after the first few weeks as their bodies adjust.
When you start an AI, keep a simple log of any new symptoms. That makes it easier for your doctor to decide whether to tweak the dose or switch to another AI.
In short, aromatase inhibitors are powerful tools for cutting estrogen when it’s driving disease. Knowing the main types, typical side effects, and how to monitor your health can help you stay on track and get the most benefit from your treatment.
A clear, up‑to‑date guide on Aromasin (exemestane) covering how it works, proper dosing, common side effects, safety tips, and alternative options for hormone control.